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They phased them out over six months, so I was on a minimal dose.
Finally, a minimal dose 4 mg/day was sustained with optimal results.
The RO5126766 at the concentration of 0.3 μM was a minimal dose demonstrated reduction of ERK/MEK phosphorylation to undetectable levels in HCT116 (K-ras) cells after 2 hours of the treatment start [24].
Recent research has shown that a minimal dose of chlorhexidine (0.06%) has no beneficial effect on the oral health of aligner wearers [9], who must keep their appliances in place for 22 h per day in order to ensure good orthodontic outcomes (though it should be mentioned that many patients also keep their aligners on while eating and drinking).
We decided to try it out the adult way and started out with a minimal dose -- a quarter of a trip on a Sunday afternoon.
However, extinction was achieved with a sequential treatment, first with ribavirin, and then with a minimal dose of 5-fluorouracil in combination with guanidine hydrochloride.
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Subsequent experiments showed that this adaptive response to low doses requires a certain minimal dose before it becomes active; occurs only within a relatively small window of dose; is dose-rate dependent; and depends on the genetic constitution of the people or animals exposed, with some being unresponsive.
We found that a rather minimal dose of cowhage, approximately 45 spicules, equivalent to 45 µg of material (maximally containing about 90 ng of mucunain) induced a more intense itch sensation compared to histamine, at a dose of 6 mg histamine (base) that was contained in the chamber of the drug delivery electrode.
Gamma irradiation is commonly used to disinfect bone grafts whereas a standard minimal dose of 25 kGy is recommended by the International Atomic Energy Agency, IAEA [ 40].
A single, minimal dose endorphin treatment at weaning life-long influences the endorphin and serotonin content of immune cells, cells of some brain regions, the binding capacity of uterine estrogen receptors, and sexual activity (Csaba et al. 2004a, b, c).
Despite the disadvantages, several experimental studies have shown that efforts to restrict respiration-associated tumor motion and optimize the planning target volume (PTV) margin lead to an acceptable minimal dose error [ 8– 10].
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