Whilst there was a small, but significant difference in the level of bacteremia between strains 1861 and 4496, this difference was minimal compared to strain 1.
It's a small but significant difference.
In a previous study [ 23], a difference in SPADI score of 10 points or more was chosen as a minimal clinically significant difference in shoulder pain and function.
With an alpha error of 0.05, a beta error of 0.2 and a minimal clinically significant difference of 6.7 points corresponding to 1/3 of the documented mean improvement, the minimum sample size was 83 for each group.
The minimum sample size was calculated assuming a 5% risk and an 80% potential for detecting a minimal clinically significant difference between DVP and PVC indicated for each laboratory test, standards which were agreed by the research team and all laboratory, internal medicine and emergency medicine medical staff.
20 The sample size was based on detecting a minimal clinically significant difference of 6 (SD 10) points on the global assessment of functioning scale at 24 months, between those randomised to art therapy and those randomised to active control or standard care alone.
An analysis of loss to follow-up in the RHINE population suggests a minimal non-significant difference in associations between respiratory symptoms and sex and age among responders and non-responders during follow-up [ 40].
When tadalafil 10 mg and 20 mg was administered to healthy subjects, minimal, but statistically significant differences over placebo in standing systolic (SBP) and diastolic blood pressure (DBP) were observed.
We calculated (α=0.05, 1−β=80, two tailed test) that with 219 pregnant smokers in each group and with a common standard deviation of 350 g we could have shown a between group minimal, statistically significant difference of 100 g, which we considered as clinically significant.
The threshold for clinical significance or minimal clinically significant difference (MCSD) on the SGRQ total score is a change in 4 units [ 32].
