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Lastly, one might expect a milder reduction of iCa amplitudes in mdx muscle fibres, as a large fraction of DHPR should not be directly affected by the absence of dystrophin because (i) dystrophin is poorly expressed in the t-tubules as compared to DHPR and (ii) colocalization in wt fibres was about one third.
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In contrast, MRI findings were substantially unmodified, showing only a mild reduction of brain sagging, with persistent subdural fluid collection in the same regions, epidural venous engorgement and diffuse meningeal enhancement in supratentorial and infratentorial regions (images not shown).
A simple chemical approach has been developed for the synthesis of graphene through a mild reduction of graphene oxide (GO) using metal nanoparticles as the catalyst for the hydrolysis reaction of NaBH4 at room temperature.
Therefore, the mitochondrial ATP generation is also reduced and addition of oligomycin able to promote a mild reduction of intracellular ATP in HPC compared to LPC (Fig. 2c).
When the LXR-agonist TO1317 was added to the palmitate conditions, it gave a mild reduction of palmitate toxicity in fa/fa beta cells, whereas fa/- cells were efficiently protected.
This animal model reflects the pathogenesis of human spinocerebellar ataxia [24], and exhibits extensive cerebellar atrophy, including a substantial loss of Purkinje cells and a mild reduction of granule cells, along with decreased thickness of the molecular layer and internal granule layer.
These interventions resulted in only a mild reduction of temperature, reaching 37.6 °C after 4 h (Fig. 2 a).
Thus, TGF- β1 led to a mild reduction of Runx2 mRNA expression in Panc-1 cells and IPSCs.
A large-scale screening study for genes in yeast displaying haploinsufficiency found that haploinsufficiency of coq6 resulted in a mild reduction of fitness in a medium containing glucose.
In our patients older than 70 years of age we found a mild reduction of QoL and a rising problem concerning dyspnoe.
Nevertheless, these results show that a mild reduction of homotypic early endosome fusion was sufficient to modify cell fate and induce neuronal differentiation of PC12 cells.
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