Conversely, expression of the small GTPase Rheb, which activates TOR signaling, leads to a mild cell size increase under conditions of nutrient abundance and to a stronger one under starvation, as has been reported previously [18], [19].
In both RCTs versus placebo, the trend toward improvement in FVC suggests that the efficacy of CYC on lung function is limited, as also corroborated by a mild effect size (Table 1) [ 2, 3].
No parenchymal lacerations can be observed, but an active contrast material extravasation (arrow) is recognisable within the haematoma during the arterial phase, showing a mild increase in size during the nephrographic phase as a consequence of a capsular artery rupture Arterial pseudoaneurysm (not included in the AAST classification).
While in P6, and P7 samples we noticed the presence of two populations of muscle fibres (predictably normal size and severely atrophic), P8, and P9 showed a mild variation of fibres size without any particular topography (not shown).
By Alcian blue and Alizarin red staining of the skeletons, a mild reduction in the size of the skeleton (data not shown) was noted, but there were no patterning defects observed in the P1 transgenic mice.
There was a mild reduction in the size and number of the islets in this group.
RNAi knockdown of Ncoa6 resulted in a mild decrease in eye size (compare B to A ). (C ) UAS-Dicer2/+; GMR-Gal4/+; UAS-trr RNAi/+.
In addition, as reported (Beller et al., 2008; Soni et al., 2009), ATGL fails to target LDs leading to a defect in lipolysis and a mild increase in the size of small LDs.
In contrast to the massively enlarged lysosomal structures observed in lrrk NS flies, lrrke03680 homozygous flies showed a mild increase in the size of the Rab7-positive late endosomal compartment in a subset of cells (supplementary material Fig. S2F) and no discernible change in lysosome morphology by Lysotracker staining (supplementary material Fig. S2I) (Dodson et al., 2012).
As seen in the EPICOR panel, we found LINE-1 hypomethylation also in Dutch cases as compared to controls, although with a milder effect (effect size ± se = −0.132 ± 0.042, 95%% CI −0.21;−0.05, P = 0.001).
