The 1993 fire caused the industry to rapidly transition from the mild onset of a shortage to a very solid shortage as a a result of the incident.
Our morpholinos behaved essentially as predicted, with the exon 9 morpholino causing a very severe phenotype and the exon 13 morpholino producing a mild, later onset motor deficit.
Do you think there is any correlation between the off-field problems that some active players face today (violence, weapons charges etc) with the mild onset of dementia or other effects of trauma from playing contact sports?
These animals displayed age-dependent deterioration of the NMJ that correlated with progressive signs of denervation and a mild late-onset motor neuron pathology.
We have shown a mild delayed-onset liver injury in C57BL/6 mice that may be the basis for an animal model if a method can be found to increase liver injury.
As mentioned earlier, V804M is a well-described gatekeeper mutation associated with a mild, late-onset phenotype, which could explain its rare occurrence in the presumably healthy cohort (1/13 000 alleles in the ESP dataset, 0.00007).
Severe cystic kidney disease was evident with Pkd1 deletion before 13 days of age; by contrast, Pkd1 deletion after 14 days of age caused a mild, slow-onset cystic kidney disease, demonstrating a developmental or possibly growth-related switch (Piontek et al., 2007).
Whereas WD is a severe, early onset illness caused by complete loss of LAL activity, CESD is a milder, later-onset disease resulting from partial LAL deficiency that is often accompanied by dyslipidemia and a predisposition to atherosclerosis (Scott et al., 2013, Grabowski et al., 2015).
