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While a mild decrease of p-ERK1/2, p-AKT, and p-IKKα was observed on the xenograft samples from mice treated with ursolic acid alone, oxaliplatin alone did not seem to have obvious effect on the phosphorylation status of these three molecules tested (Fig. 5A).
In contrast, OCT1 silencing only induced a mild decrease of p-RSK level (see online supplementary figure S5).
Actually, it could be hypothesized that a (mild) decrease of Complex I efficiency, by maintaining high levels of NAD+, could be advantageous for longevity.
Actually, in the present study, the patients with a mild decrease of blood pressure in a middle-dose group has recovered soon without any treatment.
In theory, a certain degree of interspinous elastic device loosening may occur after bone resorption, which can result in a mild decrease of the lumbar stability and subsequent postoperative pain and discomfort due to the stimulation of inflammatory factors produced during friction and bone resorption [ 37].
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Only one patient, treated with trastuzumab for more than 1 year before the addition of CM, experienced a mild decreased of ventricular left ejection fraction (less than 10% from baseline value) and trastuzumab was interrupted.
Compared to DBD/air the use of argon as working gas resulted in a milder decrease of cell number.
Previous descriptions of hyponatremia as a consequence of hypothyroidism report a milder decrease of sodium (> 120 mMol/l) and a urine osmolality of <500 mosm/kg [ 16].
This is modestly lower than the expectation of 25%, indicating a mild decrease in rate of survival to weaning for mutant pups, compared to WT and heterozygote littermates (p<0.01, chi-squared test, N = 861).
The fact that the specificity and PPV of ONSD were particularly diminished with ICP fluctuation, while the sensitivity and NPV showed only a mild decrease, is suggestive of, but certainly not conclusive evidence for, a problem with reversibility of ONSD distension.
Patients 1 and 2, harbouring the homozygous c.3900+1G>T mutation, showed a mild decrease in the synthesis of COX1, whereas the translation of other mtDNA-encoded polypeptides was the same or slightly increased compared to control fibroblasts (Fig. 6C).
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