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Furthermore, NAC treatment of wild-type and Zfp277−/− MEFs significantly repressed the expression of p16Ink4a and p19Arf (Figure 3C) and extended the cells' life span, although NAC itself had a mild adverse effect on proliferation as evident from the growth retardation of Zfp277−/− MEFs at early passages (Figure 3D).
In crosses between heterozygous mice, the occurrences of Ing2+/+, Ing2+/− and Ing2−/− genotypes were 27% (154 out of 570), 56% (319 out of 570) and 17% 977 out of 570), respectively, showing a slight deviation from the expected Mendelian distribution and indicating that Ing2 deficiency may have a mild adverse effect on embryonic or prenatal development.
This indicates a mild adverse effect of LOH events on somatic tissues that sustain a high expression of tissue-specific genes, which allow a high-level of LOH.
The LOH event in old-aged patients may exert a mild adverse effect at a late adaptation stage of newly fixed stem cells that establish a high expression of several stomach-specific genes and the down-regulation of housekeeping genes.
Therefore, it is likely that a high-level LOH resulting from a mild adverse effect of LOH in the stomach tissue environment drives the growth of a micrometastasis into a macroscopic metastasis via high-dose-compensatory demethylation.
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Light therapy has been shown to be a patient friendly, non-pharmacological antidepressant, which has an early onset of action and a mild adverse-effect profile [ 24].
It has a relatively mild adverse effect profile, with no risk of the tyramine ('cheese') reaction at normal therapeutic doses.
The mild adverse effect noted among homozygous variants could reflect a true adverse effect of hemoglobin on IQ; however, it may be an artifact due to the small number of children in this group, as evidenced by the wide variability in the effect estimate.
Mild adverse effect Injury or complication that causes none of the above.
Although this finding is similar to reports of earlier studies which reported mild adverse effect during clinical trials [ 16, 17] and among patients prescribed AL [ 22], it cannot be used to draw conclusion on the safety of AL because of the small scale nature of the study and the qualitative design both of which constitute a limitation to the generalizability of findings in this study.
As a result, mild adverse effects that may occur include gastrointestinal toxicities (nausea, vomiting, diarrhea), headache, and insomnia.
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