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Koczan and colleagues [ 52] determined pharmacogenomic differences after 72 hours in 19 RA patients (12 responders and seven nonresponders) using a microarray with a complexity of about 18,400 genuine transcripts after administration of etanercept.
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To assess the effects of added Notch and MAML-1 on the specificity of CSL for its recognized DNA target motifs, we used a microarray with 4 chambers, each containing a different preformed protein complex.
For example, the string 0010110000|01100 represents a bicluster of a microarray with ten genes, { g i}1≤ i ≤10, and five conditions, { c j }1≤ j ≤5.
Likewise, a more limited study using a microarray with approximately 2000 genes failed to distinguished morpheaform from nodular BCCs in unbiased clustering (Howell et al. 2005).
Figure 5a shows the R/G ratio image of a portion of a microarray with spatially variable, high background emissions and poor spot-specific signal in the red channel.
Using a microarray with evenly tiled probes at a density of 9 bp, we mapped and quantified the transcripts of the carbazole catabolic plasmid pCAR1 in its original host Pseudomonas resinovorans CA10 and the transconjugant P. putida KT2440 pCAR1) during growth on either carbazole or succinate as the sole carbon source.
11 Add-On normalization allows to normalize a new microarray with respect to a normalization performed for a set off arrays.
To detect and identify the pathogens responsible for sexually transmitted diseases (STDs) at the early stage of infection and with a high throughput, a new microarray with a bifunctional probe modification was prepared using Neisseria gonorrhoeae, Chlamydia trachomatis and Ureaplasma urealyticum as a model system.
Therefore a shotgun DNA microarray with a onefold coverage of the genome was used [ 41].
A sandwich of the microarray with a backing slide was hybridized overnight in a Surehyb chamber.
This platform is a high-resolution oligonucleotide-based microarray with a resolution of approximately 150 kb.
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