For this purpose we generated a novel microarray capable of measuring the differential transcriptional expression of 7068 ESTs from T. thynnus.
After we sequenced R. decussatus transcriptome we have designed an oligo microarray capable of contributing to provide some clues on molecular response of the clam to Perkinsiosis.
In the current study, we have therefore elected to use untagged human cDNA clones from the Mammalian Gene Collection (MGC) [ 9, 10] for the construction of a cell-based microarray capable of screening a large number of genes.
Towards this end, we mainly utilized a rhesus-specific microarray capable of measuring the expression of over 20,000 genes in one tissue sample.
The group of Walt recently developed the first microfluidic platform equipped with an optical imaging fiber microarray capable of detecting DNA at the attomolar level.
The present gene expression signatures may, supplemented with future signatures, form the basis for developing a universal colon cancer diagnostic microarray capable of classifying tumour origin, type, stage and propensity to metastasise, as well as predicting their response to chemotherapy and likelihood of recurrence.
In order to address this problem, we have evaluated the modulation of gene expression within the livers of mice treated with a hepatotoxic dose of acetaminophen (APAP) using high-density oligonucleotide microarrays capable of determining the expression profile of >11,000 genes and expressed sequence tags (ESTs).
Arrays are available as high-density microarrays capable of covering the whole genome of an organism, and as low-density custom arrays containing a specific set of genes.
To determine the extent of LOH, we used DNA microarrays capable of distinguishing whether the strain was homozygous for a SNP specific for the W303-1A-derived W303-1A-derived W303-1A-derivedpecific for thomolog89-derived homozygousr heterozygous.
We therefore designed Affymetrix resequencing microarrays capable of resequencing 13 genes mutated in SNHL (GJB2, GJB6, CDH23, KCNE1, KCNQ1, MYO7A, OTOF, PDS, MYO6, SLC26A5, TMIE, TMPRSS3, USH1C).
However, with the advent of new genomic technologies such as microarrays capable of simultaneously measuring thousands of genes or gene products, we are beginning to construct molecular fingerprints of individual tumors so that accurate prognostic and predictive assessments of each cancer can be made.
