Due to a lack of methodologically sound trials, this statement is associated with a high level of uncertainty.
Several reviews have suggested the importance of designing and conducting a methodologically sound clinical trial in the investigation of CI versus IB antibiotic administration benefits in critically ill patients [29, 38 40].
A methodologically sound multicenter trial involving a large patient group would solve this issue.
Several reviews have suggested the importance of designing and conducting a methodologically sound clinical trial in the investigation of CI versus IB antibiotic administration benefits in critically ill patients [ 29, 38- 40].
As a consequence, the outcomes gathered from rigorous and methodologically sound trials may not be generalizable to users within the community.
However, the paucity of methodologically sound trials prevents definitive interpretation and may obscure risks.
The lack of coherent research, and need for methodologically sound trials provides the basis for this proposed trial.
Interviews followed a semi-structured format built upon the results of the survey and were focused on participants' experiences and attitudes towards conducting pediatric research and how these interacted with the appropriate design and conduct of methodologically sound trials.
8 9 10 11 Trials that have reported large effects on joint pain were often hampered by poor study quality and small sample sizes, 9 10 11 12 whereas large methodologically sound trials often found only small or no effects.
10 The initial pooled effect size of −0.75 (−0.99 to −0.50) in favour of chondroitin sulphate diminished to zero when the analysis was restricted to methodologically sound trials of adequate sample size.
The strengths of our analysis are that we analysed a large number of individual patient data in a clinically important chronic pain condition, using validated instruments for measuring clinically important trial outcomes, based on large, modern, rigorous, and methodologically sound trials.
