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These data identify CLEC12A as early adaptor molecule for antibacterial autophagy and highlight perturbational profiling as a method to elucidate defense pathways in complex genetic disease.
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Precise control of gene expression is a powerful method to elucidate biological function, and protein overexpression is an important tool for industry and biochemistry.
Fragment-based drug discovery is a powerful method to elucidate novel binding sites within proteins, and the method has had significant success in the context of HIV proteins.
Mass spectrometric structural analysis of crosslinked peptides is a powerful method to elucidate the spatial arrangement of polypeptides in protein complexes.
Analyzing ancestral sequences is a powerful method to elucidate the evolution of opsin sequences [23], thus we reconstructed ancestral RH1 sequences for internal nodes of the species tree and inferred the changes that occurred on each lineage.
Structural brain imaging is assumed to be a key method to elucidate the underlying neuropathology of bipolar disorder.
Structural and functional imaging is assumed to be a clue method to elucidate the underlying neuropathology of this disorder.
Thus, GeF-seq is a powerful method to elucidate the molecular mechanism of target protein binding to its cognate DNA sequences.
Overall, this study provides a new method to elucidate genes and functions involved in the regulation of the P. falciparum cell cycle.
Functionally based expression profiling of the early mouse embryo is emerging as a powerful method to elucidate the regulatory networks that underlie developmental programs.
Here, we propose a novel method to elucidate gene regulatory circuits from these aggregate measurements in embryos of the frog Xenopus tropicalis using gene network inference algorithms and then test the ability of the inferred networks to predict spatial gene expression patterns.
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