The development of Genome-Wide Association Studies (GWAS), a hypothesis-free method of interrogating large numbers of common variants spanning the entire genome in disease and non-disease subjects has revolutionised our understanding of the genetics of allergic disease.
Nevertheless, this is an unusual and highly visual method of interrogating otherwise invisible concentration gradients in dynamic solutions and is an imitative example of chemotaxis that can direct the motion by sensing the location of target; this indicates potential for further interesting developments in the future.
To address this question in a comprehensive manner, we developed a method to interrogate methylation states of hundreds of sequence variants inserted at the same genomic site in mouse embryonic stem cells.
First, we interrogate and justify the relevance of bead endocytosis as a method of cellular internalization of 1-μm probes in FLTM.
"Bisulphite-tagging," a method that interrogates the methylation status of the CpG site within TaqI (5′-T′CGA) and MspI (5′-C′CGG) restriction sites in the genome, was applied to DNA isolated from three CRC cell lines, SW480, HCT116, and LIM1215, as well as to DNA from eight pairs of CRC and matched normal tissue samples,.
Here we report the development of the Golgi two-hybrid (G2H), a method that interrogates protein interactions within the Golgi, where transcriptional activators can be assayed with negligible background.
Literature Lab represents a method to comprehensively interrogate the literature for associations between a list of genes and a list of key terms in an unbiased manner in order to highlight potentially important biological processes implicated by the gene list.
Lineage tracing using inducible genetic labeling has emerged to be a powerful method for interrogating the developmental fate of cells in intact tissues.
Targeted assembly is a powerful method for interrogating large data sets for the presence of sequence variants of interest.
A more global method for interrogating the data presented in this report is to make use of web-delivered tools to discover possible networks or canonical pathways.
