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Participants were divided into four groups according to manganese (Mn) cumulative exposure index (Mn-CEI) levels: an internal control group (Mn-CEI <1.0 mg/m year), a low exposure group (1.0 mg/m year≤Mn-CEI<2.0 mg/m year), a medium exposure group (2.0 mg/m year≤Mn-CEI<5.0 mg/m year) and a high exposure group (Mn-CEI≥5.0 mg/m year).
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Mortality owing to PD was also examined in the subcohort of workers who were assessed to have had a high or medium exposure in the original mortality investigation.
None of the deceased workers in the high-PQ-exposure group had a death certificate that mentioned PD (0.5 expected mentions), but the one worker whose death certificate mentioned PD had held a job entailing medium exposure to PQ (1.1 expected mentions).
Mortality patterns were also examined among the group of 320 workers who had ever held a job entailing high or medium exposure to PQ.
Cells were counted in logarithmic phase (10 cells/mL, 2 mL in 6-well plates), which were synchronized by medium exposure, with a low concentration of FBS for 24 h for the induction of cell cycle arrest.
These data will be further supported by the measurement urinary albumin (dipstick and Albumin Creatinine ratio) from baseline at 48 h and 3 months post-contrast medium exposure as a measure of renal tubular function.
When we compared what proportion of residences fell into quartiles of exposure predicted by the CPUR metric when the CDWR metric was applied, we observed a substantial shift from high or medium exposure to low.
Untreated S. venezuelae conditioned medium exposure was used as a positive control.
A total of 118 workers were assessed to have held jobs that entailed high exposure to PQ, and a further 202 held jobs that entailed medium exposure to PQ.
The finding of a higher prevalence of 'any eye symptom' in the medium exposure zone compared with the low exposure zone is difficult to interpret.
Many of the recent physical and mental symptoms were only marginally more prevalent in the high than the medium exposure area, indicating that there is a threshold beyond which additional exposure does not result in increased morbidity.
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CEO of Professional Science Editing for Scientists @ prosciediting.com