Even though this assay was performed in rich medium, differences in motility were observed after 2 days in semi-solid culture and we suggest that under these conditions XacFhaB is being expressed in wild type bacteria restraining its movement.
For our primary outcomes, analyses of standardised effect sizes showed significant but small to medium differences in polysomnographic (weighted standardised mean difference −0.36, 95% confidence interval −0.57 to −0.16) and subjective sleep latency (−0.33, −0.62 to −0.04) for treatment versus control.
Compared with those with private health insurance, not having insurance was also associated with small to medium differences in 'Actively managing health' (ES −0.23 [−0.09] −0.09]), 'Social support for health' (ES −0.16 [−0.01] −0.01]), and 'Understanding health information well enough to know what to do (ES −0.27 [−0.41] −0.41]).
This improvement was predominantly attributable to a significant moderate difference in the social functioning domain [8.04 (95% CI 1.89 14.18), Cohen's effect size = 0.49] and a significant small-to-medium difference in the mental health domain [2.46 (95% CI 0.10 4.82), Cohen's effect size = 0.39] (Table 1).
Hence, using an indirect comparison, the previous studies suggest at least a medium-size difference in effect (d = 0.50) between both treatment programmes.
We anticipated a medium-sized difference in effect size between MBT-IOP and MBT-DH based on prior research.
With a sample of 100 participants per group we will be able to observe a medium sized difference between three treatment groups in our primary outcome, caregiver's perceived social support (Social Support Survey, mean 73.3, SD 20.8) (80% power, P < .05 significance) [ 62].
aunder "minimum growth" medium, differences exist in both biomass and minimum growth medium definitions between publications.
Power was calculated to detect a medium effect size difference in the primary outcome measure of patient self-report pain.
