These results provide strong support that TFEB mediates time-dependent pTau protein clearance through a cell autonomous mechanism.
L-Cysteine depletion mediated time-dependent changes in the expression of RENTs suggest that similar to other eukaryotic cells, NMD may also be functional in E. histolytica.
However, we previously observed in rats that PPARγ mediated time-dependent vasorelaxant responses to cannabinoids were only observed in conduit arteries such as the superior mesenteric artery and aorta, but not in third-order mesenteric arteries.
To investigate the adenovirus vector mediated, time dependent FasL transgene expression in engrafted human synovium in vivo, 1011 virus particles of Ad-FasL per dose were injected into the middle of the implanted human synovium in SCID mice.
All recombinant plant APCs mediated time dependent uptake of [αP]-ATP into phosphate (Pi) loaded liposomes (Fig. 1a, c, e, black rhombs) and no comparable accumulation of radioactivity was observable with corresponding vesicles lacking Pi in the lumen (Fig. 1a, c, e, open rhombs).
Vascular endothelial growth factor augments the effect of IFN- γ on the induction of IP-10 mRNA and protein expression in ECs, and Chinese hamster ovary cells designed to secrete VEGF were injected subcutaneously into the skin of nude mice and found to mediate a time-dependent increase in IP-10 mRNA (Feldman et al, 2002).
Together, these experiments suggest that the recruitment of RB to protein complexes is a dynamic, time-dependent event mediated by the increased activity of HDAC1.
Our results suggest a time-dependent, stimulus-specific regulation of mRNA synthesis mediated by ER.
JNK, p38, and ERK were activated and phosphorylated after cinnamaldehyde treatment in a time-dependent manner, which suggested that apoptosis was mediated by activation of proapoptotic Bcl-2 family (Bax and Bid) proteins and MAPK pathways [ 81].
The phosphorylation of AMPKβ, which mediates the association of the AMPK heterotrimeric complex, also decreased in a time-dependent manner.
