The chromophore absorbs photons of light, using a mechanism that involves a change in its configuration.
The bone microstructure suggests that rauisuchian osteoderms were originated through a mechanism that involves both intramembranous and metaplastic ossifications.
These structural data, along with biochemical analysis of active site mutants, support a mechanism that involves direct elimination of trimethylamine.
Actinomycin D promotes phosphorylation and accumulation of p53 via a mechanism that involves high expression of MDM2.
It specifically applies to the modeling of genotoxic interactions, where toxicants covalently bind to DNA by a mechanism that involves an electrophilic stage (i.e., polarization).
Our finding that bacterial membranes stain positive for Aβ following incubation with the peptide (Figure 2) is consistent with a mechanism that involves association with microbial lipid bilayers.
In addition, thalidomide is capable of blocking NF-κB activation via a mechanism that involves suppression of IκB kinase activity in T lymphocytes [23].
In cancer cells, AMPK is reported to be a key regulator of autophagy via a mechanism that involves inactivation of mTOR [30] and cardiac myocytes [31].
Recent reports have shown that adoptive transfer of CD4+CD25+ Tregs significantly protected against EAE and decreased CNS inflammation through a mechanism that involves IL-10 [10] [10].
Importantly, we found that the microglial effect is mediated through a mechanism that involves a soluble product(s) of microglia cells, rather than direct cell contact.
In summary, our studies show that the large immunophilin FKBP52 modulates Aβ toxicity, possibly through a mechanism that involves homeostasis of cellular copper.
