Exact(1)
Briefly, the AML method formulates the alternative hypothesis in terms of the probability that a given SNP is associated with disease and a measured effect size.
Similar(59)
When meta-analysis is applied to complex genetic syndromes, the measured effect size of a genetic variable between studies is often widely discrepant [20], [21].
In other populations, in which the dominant etiological pathway is independent of the gene variant in question, the measured effect size of the genetic variant may be small.
Thus, our measured effect size was approximately one order of magnitude smaller than prior estimates.
In addition, some aspects of our study design may improve adherence in the TAU arm, and therefore reduce our measured effect size.
In addition, different distribution of some aspects of the subject in the four arms such as severity of the disease, fundamental nutrition status, socioeconomics status etc. may interfere or reduce our measured effect size.
The measured effect size was similar but non-significant for ear and cutaneous symptoms, fever and all symptoms after exclusion of subjects with prior site exposure, which suggests that the sample sizes were too small to show significant differences within these categories.
Using measured effect sizes at a standardized time point of 14 days after first administration (a different time point than in Figures 2 4 to better align our evaluation of dose response), we were unable to observe a dose response relationship over three orders of magnitude (0.2 120 mg/kg/day) for all experiments.
The aim of this study was 1) to include structural MRI studies systematically comparing unipolar depression with bipolar disorder and healthy volunteers; 2) to consider all available structures of interest without specific age limits, avoiding data duplication, and 3) to explore the influence of factors contributing to the measured effect sizes systematically with meta-regression analyses.
Formal testing of publication bias by means of funnel plot analysis was not performed since this test requires a well-defined and well-measured effect size in all studies, which was not the case here.
Figure 2 shows how the measured marker effect sizes are influenced by frequencies of the QTL and marker and LD between them.
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