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The licensing schema is indeed associated with variations attractiveness level, not in all, but in many cases, having a meaningful effect size in a few of them.
That is, vibration resulted in a meaningful (Effect Size = 0.74) decline in tracking accuracy for the repeated sequence.
The result would still be a meaningful effect size that could be used in a sample size calculation.
We estimated that completing 76 surveys in the largest program would permit detecting a meaningful effect size (a 0.45 standard deviation difference between the 2 larger programs and a 0.55 standard deviation difference when compared with the smallest program) for the primary outcome, CHW level of activity, with 80% power and 5% significance level.
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We targeted the RD of 7.5%, because it was considered in a survey of researchers of the Pediatric Emergency Research in Canada (PERC) network as a clinically meaningful effect size that would support a practice change.
They took a skeptical approach to the analysis and pre-specified a clinically meaningful effect size that would have to be observed to indicate a potential relationship.
Such approach is also the basis for a classic power analysis, which requires to explicitly define a minimally meaningful effect size.
Current recommendations for a priori determination of the number of subjects to include in a study suggest the inclusion of sufficient subjects to maintain adequate statistical power to detect a clinically meaningful effect size [ 34].
Collectively, these sources suggest that an attainable and clinically meaningful effect size would be 0.50, which translates into a difference between mean changes of 1 unit (absolute).
Among the statistically significant main and interaction effects, the only factor having meaningful effect size is the DIF method with a medium effect size (f = 0.33), the effects of the other factors and their interactions are negligible (i.e., f < 0.10).
More work is required on what is a clinically meaningful effect sizes for the SF-36 and other HRQoL outcomes.
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