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This corresponds to a mean life span of 10.5 days.
Control animals had a mean life span of 9.54 days.
We show that mammals with higher survival probabilities have a mean life span in natural populations representing a greater fraction of their potential maximum life span.
When grown at 25°C, B. xylophilus had a mean life span (MLS) of approximately 15 days and a maximum life span (XLS) of approximately 30 days (Table 2).
The slope of this relationship (0.353±0.052 s.e.m ., however, indicated that mammals with higher survival rates have a mean life span representing a greater fraction of their potential maximum life span: the ratio of maximum to mean life span decreased significantly from >10 in short-lived to ∼1.5 in long-lived mammal species.
a Mean life span, days +/- SD.
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Mice lacking the helicase domain of the WRN ortholog exhibit many phenotypic features of WS, including a pro-oxidant status and a shorter mean life span.
Interestingly, C. elegans lacking the wrn-1 helicase ortholog also have a reduced mean life span compared to wild type worms [ 19].
The Eudragit control-fed mice had a shorter mean life span than the eRapa-fed cohort for both females (377.5 versus 411 days) and males (mean age is 368.8 versus 419.8 days).
We have previously observed that homozygous mice lacking exons encoding part of the helicase domain of the Werner syndrome gene product have a reduced mean life span of 16.5% compared to wild type mouse [ 16].
We expect that, if anything, this should increase the slope of a relationship between maximum life span as a function of mean life span: short-lived species invest more in early reproduction and therefore may senesce at younger ages relative to their mean life span compared to long-lived species.
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