Elevated TSH (>0.5 mIU/l requiring an increase in the dose of thyroxine replacement) was a study-specific AE, with a maximum severity of grade 1.
The Frosch and Kligman [ 17] observer score rates erythema from 0 to a maximum severity of 4, and wrinkles and desquamation from 0 to 3. Biometric measurements were performed under a Plexiglas hood under controlled environmental conditions (temperature 23°C to 26°C, relative humidity 25%to4545%) after at least 10 minutes of acclimatization.
Treatment-emergent rash/skin toxicity AEs occurred in 35% and 25% of patients in the bosutinib and imatinib arms, respectively, although most patients experienced a maximum severity of Grade 1 or 2. Rash/skin toxicity AEs typically occurred earlier with bosutinib versus imatinib (median time to first event, 57.5 vs. 125 days; Table 4).
An overall severity score was computed for each respondent by aggregating responses to the 20 items, to give a maximum severity score of 60.
Score components include shock (0 to 4 points), clinical history (MI, stroke, angina; 0 to 2 points), age (0 to 3 points), ECG findings (0 to 3 points), congestive heart failure (0 to 3 points), and Charlson Comorbidity Index (0 to 6 points) for a maximum severity score of 21 points [ 19].
Fluorescence detection of the lymph nodes was performed ten days after immunization, a delay corresponding to the maximum severity of the clinical signs, i.e, paraplegia with incontinence, before their progressive diminution.
Subjects were counted once for maximum severity of an event, preferred term and system organ class.
Maximum severity of myalgia on a scale from 0 to 10 (0 = no pain, 10 = maximum pain) [ 3, 6] was reported to be 5.7 (median, 6.0; min 0, max 10; n = 36).
The maximum severity of downy mildew was observed at a growth stage of R5.3 (50% of pods were ripe), with 14% and 46% of the leaf area affected in 2006/2007 and 2007/2008, respectively.
At each of these time points the physician saw the patient and estimated the severity of a maximum of four diagnoses from their perspective after they did the case taking with the patient using a numeric rating scale (NRS, 0 = no complaints, 10 = maximum severity of the occurrence of this diagnosis) [ 13].
Independently of their physicians, patients rated the severity of their complaints as they experienced them on a numeric rating scale (NRS, 0 = no complaints, 10 = maximum severity of complaints the patient could imagine for this disease) [ 12].
