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EXPERIMENTAL DESIGN: Formalin-fixed paraffin-embedded tumor samples from 108 patients with locally advanced bladder cancer, who had been enrolled in AUO-AB05/95 AUO-AB05/95rial randomizing a maximum of three courses of adjuvant cisphasen and methotrexate (CM) versus methotrexate, vinblastine, epirubicin, and cisplatin (M VEC), were included in the study.
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In our case, usually that means a maximum of six courses, but 1539 is an exception since it's at four semester hours.
Chemotherapy was administered on an outpatient basis every 3 weeks for a maximum of six courses.
Patients who showed no disease progression and/or prohibitive toxicity continued treatment for six courses, with a maximum of eight courses in case of ongoing response.
If tumour response was observed or patients were benefiting from treatment, they could receive a maximum of two courses, otherwise they came off study after one course.
Responders and those with stable disease (SD) at 6 weeks received repeated courses at 6-month intervals for a maximum of four courses or disease progression.
Treatment was planned for a maximum of four courses of dacarbazine and 6 months of interferon- α, or until disease progression.
These findings challenge recent guidelines that recommend a maximum of six courses of chemotherapy in stage IV NSCLC (Pfister et al, 2004).
immediately followed by Paclitaxel 200 mg m−2 (3-h infusion) on day 1 every 3 weeks for a maximum of eight courses (E+P).
Patients could receive a maximum of six courses if static disease was seen, but if responding they could continue to maximum response plus two courses up to a maximum of 12 courses.
Responders and patients with SD were randomized to receive maintenance with four weekly doses of rituximab administered every 6 months for a maximum of four courses (i.e. 2 years).
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