In the alignment of reads, a maximal of three mismatches was allowed within the whole read (aligner V mode).
The box plots reveal an increase in drug promiscuity rates over time, with a maximal rate of six targets per drug in 2000 and 24 targets per drug in interval >2012.
The addition of PD98059 in concentrations between 10 – 50 ng/mL reduced PDGF-BB-stimulated migration on laminin-5 (25 ng/mL) in a dose-dependent manner, reaching a maximal reduction of sixty (60) to seventy (70) percent over the range of 20 – 40 ng/mL, as shown in Figure 1 (n = 24, p < 0.005).
Regarding the latter: motes measure all face-to-face collocation events with a maximal distance of two meters between any two study participants, while the survey's contact definition only includes conversational contact.
Further we made results robust against outliers by winsorizing the CARs (all three time windows) by a maximal deviation of three times standard deviation from mean.
Using fixed parameters, 50 nt-reads and a maximal number of three mismatches in base space (equivalent to six mismatches in color space), the percentage of genome covered by M regions, after mapping with the BFAST software, was slightly lower than in color space (6.55% vs. 8.4%).
A total of 1325 deaths were recorded, with a maximal number of three deaths a day (table 1).
For the calculation of keyed ECFP_6 fingerprints, each compound substructure, with a maximal diameter of three bonds, is treated as a compound feature.
SMT C1100 shows a maximal increase of four to five-fold compared to vehicle with an EC50 of 0.4 µM (Fig. 1A).
For the calculation of unhashed Morgan fingerprints [45], each compound substructure in the dataset, with a maximal diameter of four bonds, was assigned to an unambiguous identifier.
