These results demonstrates for the first time that learning an operant conditioning task requires while learning massive modification of the neural circuits, whereas when the task is already learned, process decreases and is more related to late establishing of the neural circuitry.
An increase in fluorescein and FITC-dextrans (4 kDa/70 kDa) permeability was also observed, which can be related to a substantial opening of endothelial cell tight-junctions but without massive modification of tight-junction protein (ZO-1, ZO-2, claudin-5, occludin) immunolabeling even 8 days after 25 Gy exposure.
These previously unsuspected massive modifications of Earth's past environments are, of necessity, reflected in the evolutionary history of life.
Thus, we propose that in the beginning of learning there are major plasticity changes due to massive modifications of the pre-existent neural circuits and that when the task is learned, the remaining plasticity is more related with a late establishing and refinishing of neural circuits.
Addition of 200 mM sorbitol to the medium led to a massive and transient modification of the protein.
"Treasury had failed to ensure that the servicers had the necessary infrastructure to support a massive mortgage modification program".
The last two generations have been the frame of massive modifications in life and food habits, with people being more and more sedentary, overfed and permeated with drugs and pollutants.
In genetically predisposed individuals, the gluten exposure results in a massive production of interleukin-15, activation of intraepithelial lymphocytes, and modification of small intestinal mucosa architecture and function.
Darwin's major contribution on this issue was not to introduce the idea, but to assemble a massive compendium of data in support of what he called "descent with modification".
A massive heap of concrete beckoned.
