Employing this identical nbs1 mutant but in an atm background, massive defects in early stages of meiosis occurred, implying a role for NBS1 in the control of meiotic progression which was independent of ATM signaling [ 23].
Mice ablated for NMHC II-A die by E7.5 due to massive defects in cell-cell contacts and epithelial multi-layering accompanied by loss of E-cad and β-catenin from adhesion sites (Conti et al., 2004).
"Seventy percent of the documents had massive defects in them".
In addition, our data showing no massive defects in the apico-basal polarity of the epithelium in the choroid plexus are also in agreement with the model previously proposed for the role of cilia in CSF formation [34], [37].
Unfortunately, Vegfaa knockdown induced massive defects in vasculature in wild-type embryos, consistent with previous reports (Nasevicius et al., 2000; Weijts et al., 2012), precluding assessment of the effect of Vegfaa knockdown on angiogenesis in ptena −/−ptenb −/− embryos.
An orthopedic surgeon did a wide resection of the malignant bone tumor, leaving a massive bone defect about 11.3 cm in length.
We examined the effect of repetitive intraarticular injections of synovial MSCs on meniscus regeneration in a massive meniscal defect of pigs.
There was a massive posterosuperior defect (AAOS Type III and Paprosky Type 3B).
Though autologous cancellous bone graft is an effective way to treat small defects, it is not enough to fill massive defect.
The Guardian reported in November claims by local doctors of a massive rise in birth defects in the city, particularly neural tube defects, which afflict the spinal cords and brains of newborns.
