DOI: http://dx.doi.org/10.7554/eLife.05871.009 We next examined the ability of transgenic animals to swim against an increasing water current, an assay of cardiac function that is sensitive to massive cardiac damage and heart failure (Wang et al., 2011).
The reduced expression of PPARα target genes in ATGL knockout animals causes severe mitochondrial dysfunction, decreased rates of substrate oxidation and OXPHOS, massive cardiac lipid accumulation, and lethal cardiomyopathy within a few months after birth.
Furthermore, we had an experience of an atypical liver hemangioma - the present patient was also followed up for 6 years with a diagnosis of hemangioma - with an arteriovenous shunt in which the patient developed heart failure due to massive cardiac load [20].
On a summer eve of 2005, as I entered the Kennedy Center in Washington DC to play Hecuba, with Malcolm playing Agamemnon, I saw his face convulsed with grief: he said that my sister-in-law Kika had just called and told him of my brother Corin's massive cardiac arrest.
Furthermore, the last drug, designed to provoke massive cardiac arrest, does not always succeed in doing so, according to the Public Library of Science online journal, PLoS Medicine.America is one of very few democracies (along with Japan, India, South Korea and Taiwan) still to have the death penalty.
It might help to prevent massive cardiac loss upon injury.
Cardiac-specific deletion of the gene encoding this protein results in deregulation of PPARγ, lipid accumulation and massive cardiac hypertrophy.
Thus, LAD ligation in newborn mice results in massive cardiac tissue damage and consequent impaired heart functions.
While WT mice showed only distinct fibrotic areas, heterozygous animals developed massive cardiac fibrosis (5.2 ± 1.5% versus 14.1 ± 4%, p < 0.01).
Huss and Kelly (2004) reported massive cardiac lipid accumulation and hepatic steatosis in PPARα knockout mice after fasting or pharmacologic inhibition of fatty acid oxidation.
