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Among other purposes, such cascades can lead to a massive amplification of the original signal [20].
Proteolytic maturation of this precursor protein leads to a massive amplification of the immune response [ 56].
In parallel, a massive amplification of COX-2-dependent prostaglandin E2 synthesis was detected in A549 neutrophil co-cultures.
The AB tumor subpopulation in the lower regions contained a massive amplification of the KRAS oncogene and homozygous deletions of the EFNA5 and COL4A5 tumor suppressors.
Conversely, other models (Dehaene et al., 2003, 2006) suggest that conscious perception relies on a massive amplification and cortical broadcasting of stimulus-specific information.
Since, in theory, an unlimited number of ligation, rolling circle DNA synthesis and nicking reactions could be performed, a massive amplification is possible.
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We find no evidence of a similar massive amplification of serpin genes in the Drosophilid lineage, although the melanogaster Spn77B and Spn88E clusters appear to represent recent tandem duplications.
Such an intragenomic conflict is expected to lead to massive amplification of gene number on both chromosomes due to an "arms race" between the conflicting genes [ 34].
Interestingly, the most BA-responsive RMS cell line, RMS-13, is known to display an activated hedgehog pathway caused by a massive DNA amplification of the GLI1 locus (Roberts et al, 1989).
Furthermore, repeated stimulations of patients'TIL with the pDC line pulsed with a mix of the 4 melanoma peptides led to the massive amplification of specific T cells for at least 3 antigens (Figures 5C and 5D).
A peculiar hybridization pattern was observed for BvMSat08, which shows massive amplification of signals in the intercalary heterochromatin, which are localized on one chromosome arm of a single chromosome pair indicating very large arrays of multiple BvMSat08 copies or clustering of arrays.
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