Sentence examples for a massive activation of from inspiring English sources

Sepsis is frequently complicated by acute kidney injury, which is associated with higher risk of in-hospital mortality [3, 4], and by disseminated intravascular coagulation (DIC) due to a massive activation of the coagulation system [5, 6].

A common feature of apoptotic cell death is a massive activation of specialized proteases, caspases, that cleave numerous structural and signaling proteins (Lüthi and Martin, 2007), yielding characteristic morphological and biochemical changes.

Participants with acute motion sickness did not only show low endocannabinoid signaling, they also demonstrated a massive activation of the hypothalamic-pituitary-adrenal (HPA) axis.

RSV infection of either non vaccinated, LT R192G) or N SRS+LT R192G) vaccinated mice induced a massive activation of BAL CD4+ or CD8+ lymphocyte subsets, with CD69 being expressed on more than 50% of the gated cells (Fig. 6A, day 10).

Severely reduced anticoagulant capacity and inhibited fibrinolysis, in conjunction with a massive activation of coagulation, lead to excessive fibrin formation and consumption of clotting factors and inhibitors.

One possible explanation for this could be that in the acute phase after HRG-β1 addition, there was a massive activation of Akt due to the already mutated PIK3CA in T47-DERβ cells, an activation that ERβ could not inhibit.

There was a low level of inherent microglia activation associated with dysmyelination, followed by a massive activation in areas of overt demyelination.

For instance, cryptogein induces a rapid and massive activation of anion channel mediated nitrate efflux regulated by Ca2+-dependent events [32], [33].

In the previous issue of Critical Care, Oshiro and colleagues [ 1] showed that changes in hemostatic competency occur early following trauma and are described by a profound derangement in coagulation, in particular massive activation of fibrinolysis and potentially fibrinogenolysis.

In acetaminophen (APAP -induced hepAPAP -induced or acute liver failure whepatocytehondeathare the primary targeted orgacutees, we found massive activation of JNK within a short period, and sustained JNK activation accompanied the reliver ofailurerom mitochondria leading to upstream activation of the mitogen-activated protein (MAP) kinase cascade.

11 In addition, the uncompetitive nature of the memantine's mechanism of action makes its antagonistic activity more potent in areas with massive activation of NMDA receptors.