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What is particularly important, the circadian components here mapped could serve as a marker for interventions, therapeutic or other.
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The slowing of EEG oscillations has been used as a marker for intervention effects in clinical trials, but the results have varied.
Clinically, the total APA is often used as a marker for nutritional intervention.
Also, the number of scheduled visits is not a direct marker for intervention intensity because a subject may have had a second visit scheduled because she missed the previous appointment.
What I'm hearing you say is that you need to specify a marker for the specific intervention that you're trying to study – that there needs to be some surrogate in there somewhere.
In patients with elevated N-terminal pro-brain natriuretic peptide (NT-proBNP), as a marker for volume expansion, sodium intervention by diet, diuretic, or both, reduces blood pressure and proteinuria, whereas a normal NT-proBNP predicts a minor or nonsignificant effect (Fig. 4) [ 30].
Consequently, variation(s) in serum aAb levels could be more relevant as a marker for efficacy in prevention rather than intervention trials (72).
However, if the psychological state is not important in those that get injured and is just a marker for a psychological trait, then longer-term interventions must be designed to change the more stable psychological traits (if these are indeed causal factors rather than markers for true causal risk factors).
In the vast majority of cases, transfusion as a specific intervention merely serves as a marker for increased disease complexity.
Politics becomes a marker for basic decency.
That transgression was a marker for everything that has followed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com