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The immunohistochemical detection of 4-HNE (another independent marker of lipoperoxidation) in the LV myocardium revealed a markedly higher response in the samples obtained from DAU-treated animals than in corresponding controls.
Silencing of both AhR and Arnt increased 1-NP-induced CXCL8 mRNA expression after 6 h exposure and protein release after 18 h exposure, with a markedly higher response in cells transfected with Arnt siRNA.
These effects are notably increased if the cells contain a wild-type p53, suggesting that although p53-independent mechanisms of apoptosis can be triggered by FFCs, the presence of a functional p53 ensures a markedly higher response to treatment.
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Moreover, in Japan, Saikawa et al. [12] reported a markedly high response rate in a phase II study of CRT involving S-1 and cisplatin for unresectable gastric cancer.
These patients, who received PV-10 to all or substantially all of their disease burden, achieved markedly higher response rates compared to patients with substantial untreated disease burden (Table 2).
19 By increasing the percentage of time required to define the responders (75 and >75% rule), we found markedly higher response rates in the mesalazine group compared with the placebo group.
However, in contrast to the short-latency monosynaptic responses in uninjured rats, these responses exhibited a long latency (9.8 ± 1.9 ms), showed greater fluctuation in both amplitude and latency (Fig. 2, A vs. I), and required a markedly higher stimulus intensity (415 ± 53 μA, 50 μs) to evoke a maximum response.
In response to the change, the body weight initially became unstable and oscillated at a markedly higher level before stabilizing and settling at a 7% higher body weight (Fig. 4).
They had more possession, more shots and completed a markedly higher proportion of their passes.
In September 2008, he revealed that his genome sequencing indicated he had a "markedly higher" risk of developing Parkinson's Disease.
Among these, the Ecuadorian showed a markedly higher rate of natural Leishmania infections.
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CEO of Professional Science Editing for Scientists @ prosciediting.com