The phrase "a markedly higher level of" is correct and usable in written English.
It can be used to describe a significant increase or improvement in a particular quality or quantity.
Example: "The new training program resulted in a markedly higher level of employee productivity."
Alternatives: "a significantly greater amount of" or "a considerably elevated degree of".
Treatment of macrophages with LPS, which is a ligand of Toll-like receptor 4, or with type 1 interferon greatly increases expression of cholesterol 25-hydroxylase, resulting in a markedly higher level of oxysterol in the blood 44, 45.
Our results showed that there was no difference in Rankl expression; however, Nur77 KO osteocytes express a markedly higher level of Opg, leading to a significantly lower Rankl/ Opg ratio.
Compared to Cabernet Sauvignon, Shiraz had higher levels of astilbin (3-fold) and hydroxybenzoate (1.7 - 3-fold), whereas Cabernet Sauvignon sap was characterized by a markedly higher level of epigallocatechin (6.3-fold) than Shiraz.
We show that the VCaP cell line exhibits a markedly higher level of rolipram-sensitive PDE4 activity (12.7 pmol per cAMP per min per 1 000 000 cells) compared with that exhibited by PC3 cells (0.2 pmol per cAMP per min per 1 000 000 cells; P<0.0001).
Second, there was a markedly lower level of HDLC in Desert subjects and a markedly higher level of HDLC in Turpan subjects, resulting in significantly different patterns of the TC:HDLC ratio, which is commonly used as a predictor of cardiovascular incidents and death, 16 17 suggesting different possibilities for the role of HDLC in the elevated risk of CVD in the two subgroups.
On the one hand, we found for intron flanking regions of PΔ4 splicing exons a markedly higher level of conservation as compared with CEs, ranging up to 80 nucleotides, while we found for intron flanking regions of DΔ4 splicing exons a conservation level similar to CEs.
In wild-type mice fed HF diets for 16 weeks, a markedly high level of cytoplasmic vacuolation of hepatocytes around the portal vein was observed compared with that in cells around the central vein (Figure 1B).
The asymptomatic ratio among schoolchildren in Taipei City, the only urban city in our study with markedly higher level of education among parents compared to other rural areas, is significantly smaller than that of the other rural locations.
As shown in Table 3, HC goats showed markedly higher level of free LPS concentration in rumen fluid than LC goats (p < 0.01), while there was no significant difference of free LPS concentration in colonic digesta between HC and LC goats (p > 0.05).
The finding of low plasma fibulin-1 in diabetic patients was unexpected, as a previous study by Cangemi et al [ 11] reported markedly higher levels of plasma fibulin-1 in patients with type 2 diabetes than in non-diabetics.
p21 expression in isogenic cell lines directly correlated with markedly higher levels of MGMT mRNA, protein, activity and greater resistance to alkylating agents.
