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His cerebrospinal fluid had five nucleated cells per cubic millimeter and a markedly elevated level of protein 119 mg/dl (normal, 10 to 40 mg/dl).
Hence, she is unlikely to have been exposed to a markedly elevated level of testosterone during fetal development.
It was previously reported that both G6pc−/− mice and GSD-1a patients exhibit increased peripheral neutrophil counts and elevated serum cytokine levels (Kim et al., 2007), and that hepatic injury in G6pc−/− mice is evidenced by necrosis and a markedly elevated level of infiltrating neutrophils (Kim et al., 2008).
A markedly elevated level of IL-18 was seen in the Gram-positive sepsis group as compared to healthy controls (p < 0.01), but only to a moderate extent in the shock group.
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A diagnosis of HPS can be made if at least five of the following criteria are met: fever; hepatosplenomegaly; haemophagocytosis; cytopoenia in at least two cell lines; a markedly elevated ferritin level; high triglycerides or a low fibrinogen level; high levels of soluble interleukin 2 receptor/CD25 and little or no natural killer (NK) cell activity.
The course of pregnancy, including risk of miscarriage and preeclampsia, has been addressed in a study of a subset of women exposed to markedly elevated levels of PFOA in the Mid-Ohio Valley (Stein et al. 2009).
In studies conducted >60 years ago, mepacrine (quinacrine [Atabrine]), an acridine with structural similarities to chloroquine, markedly elevated levels of pamaquine (plasmoquine, an 8-aminoquinoline predecessor of primaquine) (21, 22).
The family first became aware of the possibility of uranium exposure after a neighbor was found to have markedly elevated levels of uranium in her hair.
This single patient had MTC and was treated with an active non-GLP-1 based comparator; the patienon-GLP-1 basedly non-GLP-1 basedonin level before initiating non-GLP-1–based comparator therapatient
These findings are also consistent with the growing evidence that severe ATN diagnosed by markedly elevated levels of AKI biomarkers is a useful predictor of the requirement for acute renal replacement therapy in AKI patients.
Type 2 diabetes is a common metabolic disorder defined by the presence of markedly elevated levels of plasma glucose [ 1], which arise from dysregulations in the complex interplay between pancreatic β-cell function and insulin sensitivity in hepatic and skeletal muscle cells.
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