Thus, administration of either compound within 1 hour after disease induction was markedly effective across a representative range of local and systemic biochemical, immunologic, and histologic disease responses.
The patients were discriminated into three classes according to their therapy effectiveness: therapy effectiveness being more than 65% was regarded as markedly effective, 65%~26% effective, and less than 26% ineffective.
Also, because the cell cycle analysis, bright field microscopy and β1-integrin expression revealed a markedly lower effective concentrations (1 10 μg/ml) of the plant extracts.
67 (91.8%) trials reported the efficacy standard, but 51 (69.9%) out of 73 trials used composite outcome measure which categorized the effect of the treatment into four grades (cured, markedly effective, effective, ineffective) according to the change of the symptoms, the remaining 16 trials (21.9%) used single outcome measure for therapeutic effect.
It was confirmed from the experimental results that the proposed MIP-carousel process was markedly effective in separating Cu2+ from Mn2+ and Co2+ in a continuous mode with high purity and a relatively small loss.
However, the common use of "clinical efficacy rate" as an ancillary outcome measure through subjective qualitative scores such as "clinical cure", "markedly effective", "effective", and "ineffective" in Chinese are not internationally recognized, and the validity and reliability of that was uncertain in assessing the outcome.
This study suggested that nimodipine could be markedly effective to reduce edema and hematoma volume when administered in combination with other neuroprotective agents because ICH can induce brain injury by multiple mechanisms.
All the synthesized compounds proved to be markedly effective against human tumour cells: A549, HeLa, T47D and TOV112D and more cytotoxic than pemetrexed against A549, HeLa and T47D cells.
The diet was markedly effective for 3 patients (33%) and effective for 3 patients (33%).
The efficacy was evaluated as completely headache free, markedly effective (attack reduction >75%), effective (reduction >50%) or invalid (reduction <50%).
The results showed that the total effective rate of the treatment group was 92.42% and that the markedly effective rate was 56.06%, which were superior to 83.33 and 26.67% of the control group (P < 0.05).
