In fact, chronicity and joint erosions of IC arthritis are markedly amplified by the presence of a T cell component.
Correspondingly, supplementation of exogenous recombinant IL-7 markedly amplified and sustained polyfunctional CD4+ effector cells, resulting in improved therapeutic outcome in a mouse lymphoma model.
In the UK, the death of the Big Brother celebrity Jade Goody from cervical cancer in 2009 markedly amplified the number of women getting smear tests.
Both effects are markedly amplified with increasing initiator surface density, thus limiting the density of high molecular weight chains grafted from the surface.
Furthermore, non-cytotoxic levels of doxorubicin markedly amplified this difference by increasing free unbound caveolin-1 and resulted in enhanced caveolin-mediated nanoparticle endocytosis in cancer cells.
Table 1a shows that glucose-stimulated insulin release from both GK and Wistar islets is markedly amplified in the presence of L-NAME.
If lung infection is combined with mechanical ventilation, air-space enlargement is markedly amplified.
This is markedly amplified by growth-inducing factors such as insulin and FGF-10 and is sensitive to mTORC1 inhibition by rapamycin.
However, the MICs of S. rimosus mutants to ampicillin, OTC, doxorubicin and ofloxacin were markedly amplified compared with controls, which suggested that OtrC could play an important role in the self-protection mechanisms of S. rimosus.
Knocking down ICER in diabetic SIECs markedly amplified the stimulatory effect of MB-cAMP on HIF-1α signaling, as exemplified by the enhancement in HRE transcriptional activity (Fig. 6C, MB-cAMP 16 hours).
The sole exception to this is the MYCN proto-oncogene, which is markedly amplified and overexpressed in ~22% of neuroblastomas and independently correlates with advanced disease and adverse outcome [ 1, 2].
