Sentence examples for a markedly accelerated from inspiring English sources

Our results are in contrast to the findings in the SR-BI KO mice that develop a markedly accelerated atherosclerosis [7 9].

Compared to single-mutant controls, both models demonstrated a highly increased penetrance and a markedly accelerated disease onset in double mutant mice.

Therefore, double-transgenic mice derived from the coexpression of these mutated genes (APP/PS1) have demonstrated a markedly accelerated accumulation of A β deposits compared with single APP-transgenic mice [ 15– 15].

Mammary overexpression of the blood vessel angiogenic factor VEGF-A markedly accelerates the formation of lung metastasis in MMTV-PyMT mice, not only by promoting tumor angiogenesis but also by sustaining tumor proliferation and survival [ 91].

Indeed, in an experimental mouse thrombosis model, a moderate iron overload markedly accelerated thrombus formation, impaired vasoreactivity, and enhanced the production of reactive oxygen species and systemic markers of oxidative stress [ 41].

uPA is synthesised and secreted as a proenzyme, whose activation is markedly accelerated upon binding with high affinity (0.1 1 n M) to specific cell-surface uPA receptors (uPAR) (Pollanen et al, 1991; Schmitt et al, 1992).

Indeed, in vitro cell culture studies using several human and animal cell lines show that the apoptosis (programmed cell death) that occurs following free radical generation is markedly accelerated in an acid environment [ 31, 32].

Yano et al. [ 60] showed that, for rats submitted to restraint and water immersion stress, the formation of gastric lesions was markedly accelerated after an increase in gastric motility and that this ulcerogenic effect may be due to the "mechanical rubbing" of the gastric mucosa.

However, the Tyr445Phe mutation results in a mix of gating current and ionic current, with markedly accelerated slow inactivation (Harris et al., 1998) (a phenotype antagonized by TEA).

The dissolution of the slag itself was markedly accelerated by TIPA in a simulated highly alkaline pore solution.

In a perfused rat model, our laboratory showed markedly accelerated clearance in the setting of membrane injury due to Triton-X 100, a membrane detergent [12].