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To determine an optimal quantitative ratio of [tau]/[DNA] at which the DNA showed a marked retardation in the gel, 26 bp dsDNA (100 ng/10 µl) was incubated with tau in TNME solution.
The results from EMSA also show a marked retardation of 13 bp DNA band in the presence of tau on the gel, but not 12 bp DNA; that is, a 13 bp DNA is a basic motif for tau protein to bind.
The lowering of plasma oxLDL results in a marked retardation of atherosclerotic progression (6).
Investigation of DNA strand breakage and repair in gamma-irradiated cells by alkaline elution demonstrated that NU1025 caused a marked retardation of DNA repair.
In contrast, blunting the expression of β-catenin or Wnt3, an extracellular Wnt ligand, leads to a marked retardation of brain growth (Machon et al., 2003; Schuller and Rowitch, 2007), resulting from a decrease in neural proliferation (Machon et al., 2003; Adachi et al., 2007) and an increase in apoptosis of neural precursors (Junghans et al., 2005).
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The SCO group showed marked retardation in escape latency, probably due to memory deficits resulting from SCO-induced impairment of learning and memory.
At 1 month of age, about half the Hq males had marked growth retardation with a greater than 30% decrease in body weight compared to wild type animals (Fig. 1D).
Six weeks later, she was admitted to the psychiatric department again with complaints of a depressed mood, loss of interest and pleasure, and marked psychomotor retardation.
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Dopamine-active antidepressant treatment strategies may be of particular benefit in a subgroup of patients with a low level of dopamine function, as reflected by symptoms such as anhedonia, marked psychomotor retardation or concomitant Parkinson's disease.
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CEO of Professional Science Editing for Scientists @ prosciediting.com