Sentence examples for a marked response to from inspiring English sources

There was a marked response to treatment across all measures (see Table 1).

Indeed, most NSCLC patients who experienced a marked response to EGFR-TKIs were found to harbor EGFR mutations.

Through modulation of the expression levels of these miRNAs, cancer cell lines demonstrated a marked response to therapeutic agents [ 110].

A marked response to azacitidine therapy (>50% reduction in colony formation assay) was detected in the three cell lines with VHL promoter methylation but some RCC cell lines without VHL TSG methylation also demonstrated a similar response suggesting that multiple methylated TSGs might determine the response to demethylating therapies.

Given the critical role of VHL inactivation in RCC, a marked response to demethylating therapy in cell lines with VHL hypermethylation might not appear unexpected, and indeed, preferential effects of 5-aza-2′-deoxycytidine treatment of VHL-methylated versus VHL-mutated but unmethylated cell lines were described in in vivo studies [ 20].

In contrast, Her2 and triple negative tumours show a marked response to Cdc7 inhibitors with potent cancer-cell-specific killing as a result of overexpression of the target protein and a result of impairment of the origin activation checkpoint due to p53 lesions.

They want to see if there's any marked response to the change in environmental stimuli (the light and sound program).

However, we cannot infer that there would not be a more marked response to different stimuli.

However, after an initial marked response to EGFR TKIs, almost all patients inevitably relapse via development of acquired resistance within a median of 9 12 months (Riely and Yu, 2015; Santarpia et al., 2015).

Most NSCLC patients who harbor activating EGFR mutations, including deletions in exon 19 or the point mutation L858R in exon 21, experience an initial marked response to the EGFR-TKIs gefitinib or erlotinib.

Patient 47: a 67-year-old BRCA 2-mutation carrier demonstrated a short but marked response to gemcitabine and cisplatin with a significant improvement in pain control and a 90% reduction in tumour marker CA 19-9.