The phrase "a marked overall decrease" is correct and usable in written English.
It can be used to describe a significant reduction in a particular metric or observation across a broad context.
Example: "The study revealed a marked overall decrease in pollution levels over the past decade."
Alternatives: "a significant overall decline" or "a notable overall reduction."
The liver was explored until a marked overall decrease in contrast signal intensity occurred or complete disappearance of contrast was reached, which, on average, occur 3 6 minutes after contrast injection.
Therefore, our findings of a marked overall decrease in fasting and postprandial IP levels after the initiation of basal insulin treatment might have important implications not only for metabolic control, but also for cardiovascular risk reduction in individuals with type 2 diabetes.
For sizes exceeding 8 cm a marked decrease in overall and cancer-specific survival was observed for non-metastic GIST patients.
Amino acid deficiency, for example, causes a marked decrease in overall DNA methylation, along with abnormal expression of the normally silent, paternally imprinted and growth-related H19 allele in cultured mouse embryos (Doherty et al. 2000).
The aggregate expression of HSPs was significantly associated (P-value = 0.0032) with a marked decrease of overall survival rates: the median survival for those patients with positivity for HSPs expression was 20.9 ± 8.3 months (with 13 deaths out of 21 patients) while was more than 57.5 months for those 10 patients without HSPs expression (only one patient died) with a power of 0.73.
Similarly, Chanques and coworkers [ 15] observed a marked decrease in the overall nosocomial infections rate in the intervention compared to the control group, as well as significant decreases with regard to VAP, central catheter-related infections, urinary tract infections, and bacteremia.
TCP1 knockdown resulted in a marked decrease in the overall amount of CSA when compared to control cells treated with siRNAs against Luciferase, whereas the levels of DDB1 remained unaffected.
These mutations led to a marked decrease in the overall thermodynamic stability of the evolved KE07s and in the configurational stability of their active sites.
