The phrase "a marked overall" is correct and usable in written English.
It can be used to describe a noticeable or significant characteristic or quality in a general context.
Example: "The study showed a marked overall improvement in student performance after the new teaching methods were implemented."
Alternatives: "a significant overall" or "a noticeable overall".
There was a marked overall reduction in MBP expression seen diffusely throughout the cortex as well as the CC in P17 Olig2‐TsCKOCKO brains and ~50% reduction in Olig2+ cells (Fig. 4).
Although there is a marked overall size allometry in the data set, the shape difference between the ecologically differentiated sparrows cannot be explained by differences in size alone.
CO2 and salinity had a marked overall effect on the photochemical (PSII) apparatus and the synthesis of photosynthetic pigments.
Whereas Smad3−/− mice show a marked overall deficit in weight gain throughout life, the Smad3+/−; Rab25−/− mice grow similarly to wild-type mice.
Expression of SP-CA116D led to a marked overall increase of LDH release, compared to WT cells, suggesting a reduction of cell viability.
Relative to trophectodermal cells, the pluripotent inner cell mass of blastocysts show a marked overall reduction in euchromatic of both 5hmC and 5mC staining, and a progressive reduction of mC staining from heterochromatic foci.
The marked overall increase in total eGFP expression with LPS (Fig. 7B) therefore indicated that many MHV-68-exposed macrophages were infected but gM-eGFP−.
The King returned to Parliament to mark overall victory in World War II.
By 9.5 dpc PRC2 enrichment is no longer detectable, correlating with a marked reduction in overall levels of PRC2 proteins [19].
Histologic analysis of coronal sections of Tak1col2 tibias confirmed a marked reduction in overall size.
In H2O2-treated cells, a marked reduction in overall staining was observed along with aggregates in a cytoplasmic location within the cell body.
