Sentence examples for a marked modification from inspiring English sources

The present study, demonstrating significant correlations between age and inflammatory mediators of the eicosanoid and MMP pathways in whole buccal saliva from healthy volunteers, points to a marked modification of the inflammatory state of the oral cavity associated with age.

OPN in concentrations from 1.59 to 3.82 μM caused a marked modification of crystal shape with increasing concentration.

From Figures 2(a) and 4, a marked modification of the time-related trends for several metabolites starting from the 12th hour after death can be evinced.

Since these zones correlate with a marked modification of the structure of the patch system, orientation pinwheels may not be merely a consequence of mapping several functional modalities onto an overlapping representational space, as suggested by Swindale et al. (2000).

In particular, it has been shown that proteasome blockade by proteasome inhibitors resulted in a marked modification of gene expression and activity of MMPs (upregulation of MMP-1, -3 and downregulation of MMP-2, -9) and TIMPs (downregulation of TIMP-1).

Unexpectedly, we observed a marked modification in N1E-115 cell size (Fig. 2a and 2c): both HIF2α clones displayed an average 30% increase in cell diameter (p < 0.001), while HIF2α(1 485) cells were 15 to 25% smaller than native or pCDNA3.1-transfected cells (p < 0.001).

It has been clearly documented that the remodelling of endothelial cells due to LSS is associated with an increase of proteoglycan distribution and marked modification of gene expression, resulting in protection of the endothelial layer from atherosclerosis [ 8, 9].

On the contrary, the third group of patients that never reached BNP <250 pg/ml at discharge displayed marked modification of the prognosis with high rate of complications, death, and rehospitalization.

Differences on the absorption process were not found, however; marked modifications on the distribution process were eloquent.

Further investigation of minor variant models by Little et al. [ 6] did not suggest marked modifications to these conclusions.

The silencing of the SBEIIa gene caused marked modifications on amylose content, granule morphology and starch composition.