The phrase "a marked indication" is correct and usable in written English.
It can be used to describe a clear or noticeable sign or signal of something.
Example: "The sudden drop in temperature was a marked indication that winter was approaching."
Alternatives: "a clear sign" or "a distinct signal".
Approved first in Europe in 2009, its initial CE-marked indication was extended in 2017 for patients who require blood purification, including those requiring continuous renal replacement therapy (CRRT), and in conditions with excessive endotoxin and inflammatory mediator levels [5, 9].
The reason is that a marked packet is an indication of network congestion.
We show that the immunological parameters considered in our study present a marked co-variation structure; an indication that multivariate statistical methods are needed to derive a clear association between infection state and immune response.
We found no indication for a marked synergistic interaction of dioxinlike fly ash components in the bioassay.
The ability to choose an agent on the basis of its efficacy and safety profile, and to match it to a patient and an indication, is a marked advance in our ability to address an important unmet need and prevent mortality and serious morbidity in patients at risk for thromboembolic disease.
Despite a marked increase in nutraceutical use for all indications over the past decade [ 17], few studies have investigated their use by people with OA.
While there was no indication of substantive progress, there was a marked change in tone afterwards.
Moreover, there was little indication that PTSD is associated with a marked change in the way negatively valenced information, not of personal significance, is processed.
With all three compounds, as well as CA-4 and 12b, a marked increase in the mitotic index occurred, a strong indication that at the cellular level the antiproliferative mechanism involved an interaction with tubulin.
In both cases the indication was a synostosis of the knee with a marked flexion contracture due to purulent infection in the former case and tuberculosis in the second.
