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The phrase "a marked increases" is not correct in written English.
It should be "a marked increase" to maintain grammatical agreement in number.
Example: "There has been a marked increase in sales this quarter compared to the last."
Alternatives: "a significant rise" or "a notable growth."
Exact(1)
Subsequent stimulation with an activating anti-Fas antibody increased the amount of MC with a sub-G1 DNA content to 50.1 ± 3.6% consistent with a marked increases in apoptosis.
Similar(59)
In solvent mixtures, miscibility pressures show a marked increase with increased carbon dioxide content.
"But it's a marked increase.
The figure would be a marked increase from an earlier projected loss of ¥280 billion.
At Nexity Bank in Birmingham, Ala., Donald Long, its president, reported a "marked increase" in C.D. purchases.
Moreover, there has been a marked increase in the amount of homework assigned.
With lunchtime approaching, there was a marked increase in shifting in the writers' office chairs.
Since 1997, there has been a marked increase in its use among amateurs as well.
The OECD's findings represent a marked increase on previous estimates of climate finance flows.
However, there has been a marked increase in spending on information security in small businesses.
He performed 111 elbow reconstructions in 2000, a marked increase over past years.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com