Replacement of either Arg or Arg with alanine resulted in a marked increase in Km value, suggesting that mutations of these residues weakened the binding affinity of the enzyme for substrate.
The replacement of slag with QP in slag/QP composites resulted in a marked increase in strength values of either autoclaved or un-autoclaved specimens.
The replacement of silica fume in CKD sludge mixtures results in a marked increase in strength values of the autoclaved specimens at all stages of the hydrothermal process.
Clinically, the Ox treatment resulted in a marked increase in TEWL values, independently of subsequent treatment with AHAPS-SiO2-NP or vehicle alone (Figure 2A).
AIRmin mice showed a marked increase in Penh values when compared to AIRmax mice).
LRT results in cellular necrosis, which then causes increased membranous permeability allowing free diffusion of water molecules and resulting in reduced DWI and a marked increase in the ADC value.
Compared to Tyr sidechain in the gas phase, a marked increase in proton affinity values of Tyr-like sidechains is observed in functionalized systems if, in addition to the proton donor –OH group, an additional –OH group is present covalently attached to the wall within hydrogen bonding distance of the proton acceptor sidechain.
For the four specimens in which the IGFBP-5 level was detectable, data showed that treatment with both anti-miR-27a and anti-miR-140 induced a marked increase in level and values of 2.0 ± 1.1 and 3.0 ± 1.0 fold increase respectively were recorded.
With the marked increase in value, Bitcoin became a target for hackers, who could steal Bitcoins through such means as obtaining a user's private key or stealing the digital "wallet" (a computer file recording a Bitcoin balance).
The major effect induced by these mutations corresponded to a marked increase in the initial fluorescence values and, for the two mutants Ala134Val and Trp68Leu, to the absence of unfolding transition at the beginning of heating (30 40°C).
L3 derived from treated embryos exhibited a marked increase in RT to electroshock, reaching values comparable with those observed in bss.
