The lessons that can be drawn from these models are that (a) they exhibited marked heterogeneity in susceptibility to the development of septic AKI that is comparable to that in humans; and (b) the differences between those animals that developed AKI and those that did not are noteworthy from both the clinical and research perspectives.
In conclusion, our results reveal a strong treatment effect and marked heterogeneity in OTU composition.
Even after performing multiple sensitivity analyses around exposure definition, outcome, and adjustment for confounders, marked heterogeneity remained a problem.
SSc phenotypes display marked heterogeneity and a complex interplay between different pathogenic processes, including vasculopathy, autoimmunity, and fibrosis.
LIMITATIONS: Few studies involved a representative sample treated in a typical clinical setting over a long duration, treatment protocols had marked heterogeneity, and substantive amounts of data about important outcomes and patient subgroups were missing.
A random effects model was preferred where there was marked heterogeneity (I2 > 50%) and a fixed effects model in other circumstances.
One intriguing observation was that in samples in which there was domination by a single genus (Pseudomonas), there was often marked heterogeneity in the numbers of OTUs.
Schizophrenia is a severe psychiatric disorder with strong heritability and marked heterogeneity in symptoms, course, and treatment response.
Despite an often short and poor overall survival, there is marked heterogeneity in the duration of survival among patients.
Tumours smaller than 5 cm have a homogeneously low signal intensity on T1 weighted sequences and marked heterogeneity on T2 weighted sequences.
There was, however, marked heterogeneity of transposon Tn2010 insertion sites within a geographic locale suggesting SPN undergoes rapid modification by this mode of genetic change.
