Sentence examples for a marked global from inspiring English sources

As shown in Figure 5A, after 72 h of oridonin treatment, heterochromatin formation were observed with DAPI staining, and a marked global increase of total acetylation of histone H3 and histone H4 were detected by immunofluorescence.

A 47 year-old male who had previously progressed through high dose IL-2, biochemotherapy and several experimental agents also had a marked global reduction in hepatic, lung and subcutaneous metastatic burden.

Economics: Facing a Marked Global Reversal, Financial Times, January 3 , 2011

A marked global protein synthesis inhibition represented an early cellular response associated with the FK866-induced energetic stress and here we show that AMPK-EIF2A is a central hub in mediating this effect and is responsible for cell fate decisions.

In a recent analysis of data from several countries around the world there has been a marked global increase in mortality from intrahepatic, but not extra-hepatic, biliary tract malignancies [ 93].

At age 15 months a second MRI displayed marked global cerebellar atrophy (data not shown).

Brain weight in stage IV CTE (n = 15) is significantly decreased; there may be marked global atrophy of the brain.

In any case, the US has now slipped below the 20% of global GDP ratio that marks global dominance.

In our study, no change was observed in AMPK activity and PPARα expression in presence of a marked reduction of global and regional LV function.

These analyses revealed that ORC1/CDC6 RNAi had a marked, nonrandom effect on global gene expression, with increased mRNA abundance for genes positioned proximal to the boundaries of the transcription units.

See related review by Rodrigo et al., http://ccforum.com/content/18/2/217 The past three decades have seen a marked reduction in the global burden of tetanus, and following the campaign directed at elimination of maternal and neonatal tetanus, the World Health Organization estimates that 58,000 newborns died in 2010, a 93% reduction from the situation in the late 1980s [ 1, 2].