The phrase "a marked failure" is correct and usable in written English.
It can be used to describe a significant or noticeable lack of success in a particular endeavor or situation.
Example: "The project was intended to improve community engagement, but it turned out to be a marked failure, leading to a reassessment of our strategies."
Alternatives: "a significant failure" or "a notable failure".
They charged that "racial disparities" in admission to the city's select high schools resulted "in large part from admissions policies that rely too heavily or even exclusively on standardized tests" and on a "marked failure to provide African Americans and Latinos with opportunities to learn the material or otherwise prepare to meet the admissions standards".
Third, in these patients there was also a marked failure to alter the apparent SID to achieve a degree of metabolic compensation (Fig. 3).
During severe sepsis occurs a marked failure of neutrophil migration into the infectious focus, which is associated with dissemination of infection resulting in high mortality.
We found moderately decreased viability in Atg7−/− B cells following stimulation, but a marked failure of differentiation into plasma cells, associated with reduced secretion of IgM.
We previously demonstrated that during severe sepsis there is a marked failure of neutrophil migration to the infection site, which contributes to dissemination of infection, resulting in high mortality.
It has been previously reported that there was a marked failure in the control effects of H1N1 to achieve increased coverage rates for pandemic influenza A (H1N1) vaccination among students and health care workers in different parts of the world [ 3, 9, 11].
It is also seeking views on "whether Local Transport Authorities should take measures to encourage competition, including whether franchising (where operators would compete for the right to provide services) might be required in cases where there has been a particularly marked failure of competition".
We show that RNAi-mediated ablation of various proteins identified in the trypanosome flagellar proteome leads to a rapid and marked failure of cytokinesis in bloodstream-form (but not procyclic insect-form) trypanosomes, suggesting that impairment of flagellar function may provide a method of disease control.
This observation is in contrast to the observation that there is a marked growth failure during this same period, as indicated by an overall group-level decline in the HAZ during the second year of life in all five cohorts.
In addition, members of the species have the smallest genome reported in the genus, which must reflect either a marked loss of retrotransposons, or failure of retrotransposons to amplify.
Subjects with renal failure showed also a marked decrease of the PLTs with appropriate staining density of the PLT granules (43 ± 12%, p = 0.000).
