The phrase "a marked disruption" is correct and usable in written English.
It can be used to describe a significant or noticeable interruption or disturbance in a process, situation, or environment.
Example: "The recent storm caused a marked disruption in public transportation services across the city."
Alternatives: "a significant interruption" or "a noticeable disturbance."
TgRCAN1 mice present a marked disruption of the learning process in a visuo-spatial learning task.
These changes in 5-HT and 5-HIAA levels demonstrate a marked disruption of brain 5-HT homeostasin in TPH2KO and DKO mice.
In previous work, our laboratory constructed a phoP mutant from a clinical isolate of Mtb by introducing a marked disruption in the phoP gene, generating the SO2 strain which exhibited impaired multiplication in vitro in mouse bone marrow-derived macrophages, and in vivo in a mouse infection model [12].
Matrigel plug and tumour imaging after FITC-dextran injection indicated that 2-MeOE2 bisMATE caused a marked disruption of vasculature.
This view has been widely adopted [ 10] since it has been shown that psychotic symptoms contribute to a marked disruption in social and occupational functioning [ 11].
Likewise, experimental models that lead to a marked disruption of clock synchrony, such as constant light, and repetitive shifting of the light-dark cycle, have been shown to accelerate tumor growth and, relatedly, increase mortality rates [ 30- 32].
The fungi produce responses in the skin that vary from slight scaling to blistering and marked disruption of the keratin layer.
Taken together, these data suggest the expression of Bves with mutation in the putative intracellular interaction domain produced marked disruption of epithelial structure and function.
Alcohol intoxication produces marked disruption of several neuroendocrine pathways.
Fetal membrane sections from the SCS and SOR exhibited marked disruption and swelling of connective tissue.
Among the alk en yl trisulfides, DATS, dibutenyl trisulfide and dipentenyl trisulfide, all unsaturated sulfide compounds, caused marked disruption of microtubules and prominent cell cycle arrest during the mitotic phase; whereas the saturated sulfide compounds showed very little effect.
