The phrase "a marked decrease in the expression" is correct and usable in written English.
It can be used in contexts discussing changes in levels or amounts, particularly in scientific or analytical writing.
Example: "The study revealed a marked decrease in the expression of the target gene after treatment."
Alternatives: "a significant reduction in the expression" or "a notable decline in the expression."
Moreover, we have recently reported that downregulating galectin-1 expression in Hs683 human glioma cells through targeted siRNA provokes a marked decrease in the expression of the brain expressed X-linked gene (BEX2), a feature which confers increased survival in Hs683 orthotopic xenograft-bearing mice.
RNA profiling (Fig. 2b) and GSEA (Fig. 2c, Supplementary Fig. 3a) showed a marked decrease in the expression of genes related to the pancreatic endocrine compartment in GLIS3−/− PP2 cells.
The increased miRNA activity observed is indeed reflected in a marked decrease in the expression of these target genes.
We did not study the expression of TLR9 but found that MSC induced a marked decrease in the expression of TLR2 which might explain, at least in part, the enhanced macrophage susceptibility to T. cruzi infection.
Over-expression of heparanase in breast carcinoma cells (MDA-MB-231) was associated with a marked decrease in the expression of MMP family members, yielding a mirror image of the results obtained with the Hpse-KO mice.
Comparison of 2D gels revealed that in the absence of inflammatory stimulus CF cells exhibit a marked decrease in the expression of TRX-1, PRDX-1 and 6, catalase and GST-pi, but a marked increase in SOD2 compared with normal matched cell pairs (Table 1).
Notably, there was a marked decrease in the gene expression of the cell cycle inhibitor, p27Kip1, in cultures, in comparison with their in vivo gene expression levels.
Interestingly, 5/6-Nx also resulted in a marked decrease in the renal expression of the sEH on the protein, as well as on the mRNA level (Fig. 6B).
Until day 5 post-infection, this level remained relatively stable in H3R−/− mice but at day 6, there was a marked decrease in the level of HDC expression.
In addition, immunohistological evaluation of brain sections from PML patients showed a marked decrease in the level of SF2/ASF expression when compared to normal brain sections (Fig. S2).
As expected, a marked decrease in the phosphorylation of H2AX was determined to correspond to the ectopic expression of JMJD2B in HIF-1 α-depleted CRC cells.
