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The phrase "a marked changes in" is not correct in English.
It should be "marked changes in" or "a marked change in." You can use it when discussing significant alterations or differences in a particular context, such as trends, behaviors, or conditions.
Example: "There have been marked changes in the climate over the past decade."
Alternatives: "significant changes in" or "notable changes in."
Exact(1)
ShMITF silencing in Hermes 3A cells also led to growth arrest and a marked changes in morphology, with flattening, enlargement of the cell body and reduced neurite projections.
Similar(59)
The picture, however, is changing rapidly; indeed, this year has already witnessed a marked change in Chinese attitudes.
Ms. Dorfman has seen a marked change in Kerron.
"It's clear we need a marked change in approach.
Working out a temporary agreement with Brazil is a marked change in tactics for Mr. Zoellick.
Following the election there has been a marked change in attitude".
After the attacks, however, there has been a marked change in tone.
There has been a marked change in the way people use them.
It was a marked change in atmosphere from meetings with Trump's predecessor.
This was a marked change in emphasis but not necessarily a change of position.
Time-dependent creep curves showed a marked change in strain during the initial 5 s.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com