Sentence examples for a marked amplification of from inspiring English sources

If we focus on translation regulation, some transcripts can be classified as "strong ", i.e. a low level of mRNA efficiently translated leading to a marked amplification of the cognate proteins.

In early larval development (first and second instar), AMPs undergo a marked amplification in cell number through symmetric divisions.

Moreover, we show that acute palmitate-stimulating effects on insulin release were associated with increased ncNOS-derived NO generation, the inhibition of which by the ncNOS inhibitor L-NAME resulted in marked amplification of palmitate-induced insulin response.

In mouse cells, autostimulation of the IFNAR by early secreted type 1 interferons results in marked amplification of IFNα production [ 30- 33].

Immunohistochemical analysis revealed marked amplifications of both platelet binding and platelet factor-4 within the blood vessels of prostates from mice receiving micronutrients only.

The latter results in a marked attenuation of the amplification loop initiated by the binding of type I IFNs to their cognate receptor.

Specifically, the first group is characterized by MYCN-amplification, poor prognosis and therapy resistance, coupled with a marked rise of miR-17-5p level and a dramatic decrease of p21.

In GK rats, amplification of insulin secretion by incretins was much reduced, with a marked suppression of glutamate production by glucose.

Our data demonstrate a marked loss of 30% of truly differentially expressed genes after a second round of amplification.

Interestingly, after 12 h of treatment, we also observed a marked decrease of ALK phosphorylation in each of the NB cell lines harboring ALK mutation or amplification, and the unphosphorylated status of ALK was still present at 48 h.

For both species, the results indicated a marked overabundance of the TIR-220 sequences when compared with the TIR-FD probe, thus supporting the amplification of the former within Tetris.