The phrase "a marked activation of" is correct and usable in written English.
It can be used in contexts such as scientific or medical writing to describe a significant increase in activity or response in a particular area or system.
Example: "The study revealed a marked activation of the brain's reward centers in response to the stimulus."
Alternatives: "a significant increase in" or "a notable rise in".
This debilitating condition is associated with a marked activation of NFκB activity.
Using an antibody specific for the phospho-Tyr416-activated form, we observed a marked activation of Src kinase 6 h after LD in the eye-cup and in the neural retina.
Patients on extracorporeal circuits may also experience a marked activation of fibrinolysis due to release of plasminogen activators from endothelial cells.
The experiments revealed a marked activation of PMN by the supernatants, i.e. the cells acquired an activated cell shape, released IL-8, their spontaneous apoptosis was delayed and their phagocytic activity was enhanced.
Portal hypertensive gastropathy induced a marked activation of NF-κB, accompanied by a decrease in IκB protein levels and a significant induction of nitric oxide synthase (iNOS) protein.
A marked activation of the pro-inflammatory cytokine network associated with a decreased antagonistic reaction and an increased consumption of IL-6sR became prominent in malnourished patients when they underwent intense surgical stress.
The data confirm previous studies that nonsurviving patients have a more marked activation of inflammation and coagulation, and a more severely depressed anticoagulant defense.
The static handgrip at 30% MVC performed by one hand usually cannot be maintained longer than 3 4 min, which was thought to be too short a time period for marked activation of the endocrine system.
A novel finding of our study was the marked activation of 'Galactose metabolism' at 100 vs. 80 days, a response driven primarily by the marked upregulation of UGP2 (UDP-glucose pyrophosphorylase) and AKR1B1 (aldo-reductase) (Tables 1 and 2) coupled with the downregulation of LCT (lactase) and B4GALT1 (Additional Files 1 and 3).
It remains to be determined if the marked activation of IgE isotype switching has a functional role, eg, to expedite the re-encounter with antigen.
We recently reported marked activation of the Nrf2 pathway in fibroblasts exhibiting an ATPase6 mutation responsible for mitochondrial superoxide overproduction by the respiratory chain [24].
